Combined therapy using multiple approaches has been demonstrated to be a
promising route for cancer therapy. To achieve enhanced antiproliferation efficacy under
hypoxic condition, here we report a novel hybrid system by integrating dual-model
photodynamic therapies (dual-PDT) in one system. First, we attached core−shell structured
up-conversion nanoparticles (UCNPs, NaGdF4:Yb,Tm@NaGdF4) on graphitic-phase carbon
nitride (g-C3N4) nanosheets (one photosensitizer). Then, the as-fabricated nanocomposite and
carbon dots (another photosensitizer) were assembled in ZIF-8 metal−organic frameworks
through an in situ growth process, realizing the dual-photosensitizer hybrid system employed
for PDT via stepwise water splitting. In this system, the UCNPs can convert deep-penetration
and low-energy near-infrared light to higher-energy ultraviolet−visible emission, which
matches well with the absorption range of the photosensitizers for reactive oxygen species
(ROS) generation without sacrificing its efficacy under ZIF-8 shell protection. Furthermore,
the UV light emitted from UCNPs allows successive activation of g-C3N4 and carbon dots, and
the visible light from carbon dots upon UV light excitation once again activate g-C3N4 to
produce ROS, which keeps the principle of energy conservation thus achieving maximized use of the light. This dual-PDT system
exhibits excellent antitumor efficiency superior to any single modality, verified vividly by in vitro and in vivo assay.

影响因子
8.097
论文下载
作者

Dan Yang,Guixin Yang,Shili Gai,Fei He,Chunxia Li,and Piaoping Yang.

期刊

ACS Appl.Mater.Interfaces

年份